Endocrine Abstracts

According to the novel concept bone remodeling is centrally regulated (CNS). Leptin the adipocyte derived hormone acts on hypothalamus and by increasing sympathetic activity acts on osteoblasts to regulate bone formation. In patients with schizophrenia several factors have influence on bone metabolism. Schizophrenia per se, as a disease of central nervous system is associated with increased occurence of osteoporosis. Hyperprolactinemia as consequence of antipsychotic tr...

Spontaneous subarahnoid hemorrhage (SAH) is a recently identified risk factor for hipopituitarism, especially growth hormone (GH) and corticotroph deficiencies. The aim of this study is to perform the initial screening procedure to identify the patients with increased risk of neuroendocrine dysfunction after SAH in the chronic phase and to identify the possible predictor(s) for neuroendocrine dysfunction. Ninety-one patients (30 males, 61 females), age between 19 and 69 years ...

We have previously shown impaired neuroendocrine responses to ghrelin in patients with AN. The aim of this study was to investigate the metabolic responses during infusions of active ghrelin in severly malnourished patients with AN and compare them with responses of amenorrhoic AN patients who recovered body weight (PRAN) and constitutionally thin subjects (CTS) with regular menstrual cycles and without history of eating disorder and recent weight loss. Study was approved by t...

Introduction: Cognitive functions and mood (anxiety and depression) are often impaired in diabetes mellitus (DM). Dipeptidyl peptidase-4 inhibitor (DPP-4) has been shown to exert beneficial effects on insulin sensitivity and glycoregulation in T2DM patients. Introducing DPP-4 therapy leads to maintaining control of glucose levels which could ameliorate or slow down further cognitive and mood disorders impairment.Aim: To evaluate influence of selective DP...

Introduction: The most common etiology of endogenous Cushing’s syndrome (CS) is Cushing’s disease (CD). Patients with CS also represent a model of patients with metabolic syndrome (MetS) with associated increased cardiovascular morbidity and mortality. Insulin resistance and obesity, two major characteristics of CS, lead to the accumulation of triglycerides within hepatocytes and formation of fatty liver in these patients.Aim: To evaluate the p...

Introduction: Xanthomatous hypophysitis (XH) is characterized by inflammatory infiltration of the pituitary gland in which lipid laden macrophages predominate. It can be primary (3% of all primary hypophysitis) and secondary arising in the setting of other lesions: craniopharyngioma, Rathke’s cleft cyst (RCC), adenomas (with subclinical apoplexy). It is more common in women and younger people. The clinical presentation is similar to pituitary tumors and may prese...

Introduction: Structural and functional damage of the skeletal system resulting in fractures is a common complication of CD. Due to major effect of glucocorticoids on the trabecular bone, vertebral fractures are a common and severe complication which can lead to disability.Goal: To investigate the prevalence of skeletal complications (osteoporosis, osteopenia, presence of fragility fractures) in patients with Cushing’s disease, as well as gain insig...

Objective: Ionized calcium via calcium sensing receptors (CaSR) mediates feedback inhibition of parat hormone (PTH) secretion. The aim of this study is to evaluate the difference in PTH response during calcium infusion test (CIT), between patients with primary hyperparathyroidism (PHPT) and healthy control (HC).Methods: Study consisted of 15 patients with confirmed PHPT and parathyroid adenoma (57.20±11.38yrs) and 15 healthy subjects-HC (57.20±...

Background and aim: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionary conserved and widely distributed throughout organism. Broad interest for AIP comes from involvement of loss-of-function AIP mutations in pituitary adenoma pathogenesis. The role of AIP in normal pituitary function is largely unknown. AIP is co-localized with GH in somatotroph secretory vesicles. Serum AIP protein was proteomically identified. We aimed at investigating whether AIP and GH are...

Introduction: Selenium (Se) is a trace element that plays key roles in thyroid pathology. In patients with Hashimoto thyroiditis (HT), Se supplementation might reduce antibody levels and may provide additional beneficial effects, such as on cognition.Aim: To evaluate cognitive function (cognitive decline) in patients on long-term levothyroxine replacement for primary hypothyroidism with and without selenium supplementation.Design: ...